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Fructose-1,6-bisphosphate aldolase (aldolase)
- Function The fructose-1,6-bisphosphate aldolase (FDA) catalyzes the cleavage of fructose-1,6-bisphosphate into dihydroxyacetone-phosphate and glyceraldehyde-3-phosphate.
- Structure link to E. coli-Genome Database (ECDC): fba, fda (EC 184.108.40.206). The molecular mass of fructose-1,6-bisphosphate aldolase is 39.016 kD.
- Regulation / mode of operation The FDA requires the divalent cation Zn of many microorganisms in comparison to vertebrates2+. From a chemical point of view, the catalyzed reaction is an aldol condensation. This reaction is reversible.
- Enzymatic reaction fructose-1,6-bisphosphate ⇌ dihydroxyacetone-phosphate + glyceraldehyde-3-phosphate